Technologies

AGC supports a wide range of custom manufacturing projects.

  • Fine Chemicals
  • Electronic Materials
  • Agrochemical Intermediates
  • Agrochemical Active Ingredients
  • Pharmaceutical Intermediates
  • Active Pharmaceutical Ingredients (APIs)

Achieving High Reproducibility, High Quality, and Reliable Supply in Contract Manufacturing Based on an Extensive Track Record

  • A proven track record trusted by more than 110 companies across a wide range of industries
  • Expanded production capacity through continued investment
  • Resolution of all scale-up challenges from pilot production to commercial manufacturing

AGC's Synthetic Track Record at a Glance

One-Stop Support for All Manufacturing Scales with One of the Largest Reactor Capacities in Japan

Leveraging extensive experience and one of the largest manufacturing facilities in Japan, AGC supports customers in bringing their products to commercialization. To meet demands across all manufacturing scales—from pilot production to large-scale manufacturing—we are equipped with reactors ranging from 100 L to 15,000 L. By applying know-how cultivated through high-performance chemicals such as electronic materials, functional materials, and various intermediates, we provide a one-stop optimal production system tailored to each customer's business plan, covering everything from development to commercial-scale production.

Diagram showing total reactor volume at AGC Wakasa Chemical's Obama and Kaminaka plants, with GL (glass-lined), SUS (stainless steel), and HC (Hastelloy) reactors across scales from under 1,000 L to over 11,000 L.
We have one of the largest reactor capacities in Japan, centered on GL (glass-lined), SUS (stainless steel), and HC (Hastelloy) reactors.
1,000tons/year

Up to 1,000 kg per batch

Supported Production Scales

We provide a flexible, one-stop production system optimized to align with each customer's business plan.

110projects+

As of October 2025

Scale-Up Track Record

Experienced engineers support smooth technology transfer from laboratory to commercial production. By resolving challenges in process development, we contribute to maximizing the value of our customers' products.

25products

Continuously supplied (As of Oct. 2025)

Number of products in continuous supply

We continue to be selected by many customers in highly specialized fields such as high-performance chemicals, electronic materials, agrochemicals, and pharmaceuticals. With a proven track record of delivering the required quality reliably and on schedule, we contribute to our customers' business success.

0.01% or less

2008–2025

Quality Deviation Lot Rate

Under a rigorous quality control system, we maintain an exceptionally low rate of quality deviations, delivering industry-leading quality standards.

70%

In-house sourced

Ratio of Raw Materials with Multiple Sourcing

For major raw materials, we collaborate with multiple suppliers to prepare for unforeseen events. From a business continuity planning (BCP) perspective, we have established an uninterrupted supply system.

30+ companies/year

As of October 2025

Number of Customers Under Contract Manufacturing / Under Consideration

Our extensive expertise and know-how are our key assets. Leveraging this experience, we gain a clear understanding of project-specific challenges, enabling smooth and efficient project execution with minimal rework.

Cumulative Manufacturing and Development Track Record in Contract Synthesis: Over 700 Companies

To date, we have supported manufacturing and development projects for more than 700 companies. Each experience gained from meeting diverse customer needs has become a valuable asset. Going forward, we will continue to leverage our accumulated technologies and expertise to contribute to solving our customers' challenges.

List of Available Reactions

AGC is a leading chemical manufacturer equipped with world-class organic synthesis technologies, production technologies, and manufacturing facilities.
We have extensive experience in the manufacturing and handling of halogenated compounds and are capable of working with all four halogens: fluorine (F), chlorine (Cl), bromine (Br), and iodine (I).
Leveraging our extensive experience in a wide range of organic synthesis, including low-temperature and hydrogenation reactions, we effectively meet our customers' diverse needs.

Bond Forming Reactions

  • Enolate-Mediated Reactions
  • Amination
  • Radical Addition
  • Radical Halogenation
  • Chain Extension and Shortening (Decarboxylation)
  • Amidation

Oxidation Reactions

  • TEMPO Oxidation
  • Hypochlorite Oxidation
  • Periodate Oxidation
  • Bromine Oxidation

Reduction Reactions

  • LAH (Lithium Aluminum Hydride) Reduction
  • Catalytic Hydrogenation
  • Reductive Amination
  • Metal Reduction (Fe, Zn)
  • Silane Reduction

Aromatic Substitution

  • Friedel-Crafts
  • Halogenation
  • Suzuki coupling
  • Buchwald coupling

Hazardous Reactions

  • Cyanation
  • Fluorination (F₂ Gas, Chiba Site)
  • Chlorination (Cl₂ Gas)
  • Difluoromethylation
  • Balz-Schiemann Reaction (Fluorination)

Specialized Equipment & Capabilities

  • Precision Distillation (up to ~40 stages)
  • Ultra-Low Temperature Reactions (down to ~−100°C)
  • Pressurized Reactions (up to ~0.6 MPa)
  • Milling / Pulverization

Fluorine & Halogen Chemistry

  • Halogenation Reactions (F, Cl, Br, I)
  • Halogen Exchange Reactions
  • Synthesis of Fluorinated Heterocycles
  • Introduction of Perfluoroalkyl Groups
  • Advanced Corrosion-Resistant Facilities
  • Iodine Recovery and Recycling

Various Organic Synthesis Technologies

  • Amidation
  • Corey–Chaykovsky Reaction
  • Friedel–Crafts Reaction
  • Grignard Reaction
  • Various Cross-Coupling Reactions
  • Carboxylation
  • Oxidation
  • Reduction (Hydrogenation)
  • Reactions Using High-Pressure Gases (Toxic and Flammable)
  • High-Temperature Reactions (up to ~250°C, jacket temperature)
  • Low-Temperature Reactions (down to −50°C, jacket temperature)
  • Distillation (Atmospheric and Reduced Pressure)
  • Thin-Film Distillation
  • Flow Reactions (Under Development)
  • Photochemical Reactions (Under Development)

Available Raw Materials

Raw materials produced within the AGC Group.

CAS No. 76-05-1

Trifluoroacetic acid

CAS No. 407-25-0

Trifluoroacetic anhydride

CAS No. 383-63-1

Ethyl trifluoroacetate

CAS No. 2923-18-4

Sodium trifluoroacetate

CAS No. 354-38-1

Trifluoroacetamide

CAS No. 677-69-0

Heptafluoro-2-iodopropane

CAS No. 455-14-1

4-(trifluoromethyl)aniline

CAS No. 122665-97-8

4,4-difluorocyclohexane carboxylic acid

CAS No. 148043-73-6

4,4,5,5,5-Pentafluoro-1-pentanol

CAS No.30071-93-3

3,5-Bis(trifluoromethyl)acetophenone

CAS No. 3862-73-5

2,3,4-Trifluoroaniline

CAS No. 328-93-8

2,5-Bis(trifluoromethyl)aniline

CAS No. 214557-89-8

3,5,7-trifluoroadamantane carboxylic acid

CAS No. 118612-00-3

N,N-Dimethylanilinium tetrakis-(pentafluorophenyl)borate

CAS No. 136040-19-2

Triphenylcarbenium tetrakis-(pentafluorophenyl) borate

CAS No.75-29-6

2-chloropropane

CAS No. 557-98-2

2-chloropropene

CAS No. 542-75-6

1,3-dichloropropene

CAS No.96-18-4

1,2,3-trichloropropane

CAS No. 142-28-9

1,3-dichloropropane

CAS No. 96-24-2

3-chloro-1,2-propanediol

CAS No.96-23-1

1,3-dichloro-2-propanol

CAS No.627-30-5

3-chloro-1-propanol

CAS No. 616-30-8

3-amino-1,2-propanediol

CAS No.107-11-9

3-amino-1-propene

CAS No.124-02-7

diallylamine

CAS No. 102-70-5

triallylamine